- Introduction
- What’s the role of Androgens?
- Lithium and beta-catenin
- PPAR and dry eyes
- Conclusion
- References
Introduction
Accutane is well attested as being a potent and permanent solution to severe cystic acne, with at least one of its effects being a shrinking of the sebaceous glands on the surface of the skin. Whilst the latest scientific research has indicated that the structural changes to the sebaceous gland aren’t permanent – the reduction in lipid secretion is.
In fact, the mechanisms that underly Accutane’s efficacy are far more complex than the simple “shrinking of the oil glands” often touted by dermatologists. Whilst the reduction in lipid secretion is evidently beneficial in the context of acne, it can give rise to a very painful affliction of the eyes called Meibomian Gland Dysfunction. The Meibomian Glands are the large sebaceous glands that rim the eyelid, which secrete the oily meibum which protects the surface of the eyes by preventing the evaporation of the mixture of proteins and lipids called tears. [1]
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