Read through my latest articles on Post-Medication Syndromes such as Post-Accutane Syndrome, Post-SSRI Syndrome and Post-Finasteride Syndrome.
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Accutane Genetic Risk Factors
Genetic Risk Factors for Post Accutane Syndrome Whilst there’s an increasing awareness of some of the risks posed by isotretinoin treatment, from changes to vision, hair loss and even neurological changes – many dermatologists will still readily write prescriptions. Many who’ve subsequently experienced side effects often claim they weren’t adequately warned of the possible consequences, especially where more enduring symptoms are concerned. Claims of lasting changes to cognitive function appear…
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The 5-HT2A Receptor: Psychedelics and Epigenetics
5-HT2A Receptor The 5-HT2A receptor is arguably the most interesting and enigmatic of all the serotonin receptors owing to its relationship with psychedelic research. Like the 5-HT1A receptor it is a G protein-coupled receptor (GPCR) and is highly expressed in the neocortex. [1] The neocortex is most remarkable for its strong association with intelligence, particularly with respect to object spatial awareness – allowing the brain to build mental models and…
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What is the Impact of Accutane on Growth Hormone?
Introduction Somatotropin, more commonly known as Growth Hormone (GH), plays a vital role in signalling cell growth and tissue regeneration throughout the body. This hormone is particularly critical during childhood and adolescence, driving physical development and growth. When GH is secreted excessively, it can lead to conditions like acromegaly, characterised by significant increases in stature and robust skeletal development. One of the most famous individuals associated with this condition is…
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Accutane & Homocysteine: The Impact on the Estrogen Receptor
When reviewing the diverse range of the adverse responses experienced by patients treated with Accutane, one in particular stands out for it’s broad detrimental effects on general health. Accutane can trigger an increase in a particular amino acid called homocysteine. [1] Homocysteine is a byproduct of an essential process known as the methionine cycle. Simply put, methionine is a building block for producing proteins, functioning as an antioxidant, and maintaining…
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November 2024 Newsletter
Latest News Regarding SecondLife: Coupons Codes & Genetic Reporting Many of you following SecondLifeGuide.com for some time will know that a complete book on the ‘Post Accutane Syndrome’ has been in the works for some time. This website has explored the lasting adverse effects of Accutane (or retinoids more generally) throughout the body, ranging from impacts on the gut, the gastrointestinal system, and most significantly – the brain. It’s suffice…
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What Are Epigenetics?
Introduction Epigenetics is the field of genetics that explains how gene expression can be altered without changing the underlying genetic code directly. Epigenetic mechanisms can essentially switch genes on and off in a lasting manner, and thereby influence an organism’s traits and behaviour. Contrary to popular notions, epigenetic changes are not changes to your DNA (or genome) – your genome can’t be altered, or at least not without some very advanced technology. Epigenetic…
Keep readingIncreasing Androgen Sensitivity
Introduction While there is growing recognition of the importance of testosterone in popular culture—with countless online guides on boosting testosterone levels and even services offering full testosterone replacement therapy (TRT)—the critical role of the androgen receptor remains largely overlooked. These receptors are essential: without them, hormones like testosterone cannot exert their effects on the body. Even for professional bodybuilders who attempt to hack their own biology by administering exogenous androgens…
Keep readingUltimate Guide To Testosterone
Introduction Testosterone levels are declining. It’s hard to avoid noticing. Headlines reporting the steady decline in men’s testosterone are found everywhere across the internet, along with the sharp rise in the number of supplements purported to boost this vital hormone. It might seem overblown, but it’s true that testosterone is critical for male health, and it’s certainly a subject worthy of investigation. Testosterone isn’t only important for building muscle or…
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Impact of SSRIs on Early Development
Introduction While much of the discussion on the long-term adverse effects of SSRIs may seem speculative or overly reliant on indirect evidence, there is, in fact, a substantial body of research highlighting the potentially lasting effects of SSRIs. [1] The most compelling evidence for these enduring changes comes from studies in which animals are exposed to SSRIs either in utero or during early development – as well as a handful of…
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The Real Cause Of Androgenetic Alopecia
Introduction Hair loss, whether caused prematurely by medications or the inevitable process of aging, can take a massive toll on a person’s confidence. Despite how common hair loss is, particularly among men (called Androgenetic Alopecia), balding continues to be stigmatised as something unnatural or as a symptoms of poor health. The progression of the process of balding in men can be tracked along the 7 stages of the Norwood scale,…
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What Does Accutane Actually Do?
Introduction Retinoids are the class of chemicals related to vitamin A. The breadth of retinoids’ effects in the body is perhaps greater than that of any other vitamin, including vision, cell proliferation/differentiation, bone tissue, and the immune system. “Retinoid” is a general term that encompasses a range of molecules, including retinol, retinoic acid, and retinyl esters, as well as synthetic retinoids. Vitamin A stands out as one of the most…
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SecondLife: Retinoid Recovery Guide
Who’s this book for? As societal trends increasingly emphasize physical appearance, retinoids like Isotretinoin (brand name Accutane) have become a popular solution for acne and fine wrinkles. However, as the use of these medications becomes more widespread, so does awareness of their potential side effects. For most people without a medical background, their understanding of retinoids and Vitamin A is often limited to knowing they are found in red and…
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Post Finasteride Syndrome: The Complete Guide
Post-Finasteride Syndrome is the term used to describe the collection of lasting adverse symptoms that can persist long after discontinuation. These symptoms can be both physical and mental, since the hormonal target of Finasteride, Dihydrotestosterone (DHT) is central for male neurological health. In this post I detail the science underlying this chronic condition, and present evidence-based theories to explain its enduring nature. 1. An Introduction to Finasteride and DHT Where…
Keep readingQuick Read: Boosting DHT by 50% With Creatine
Introduction Whilst Creatine has long been touted as a supplement for improving strength and muscle growth, it also appears to have some interesting endocrine effects. Creatine can be obtained both through diet and endogenous synthesis, with there being around 4.5g of creatine per kilo of beef. [1] When creatine is consumed it can be converted into phosphocreatine in muscles, which serves as a rapidly useable store of high-energy phosphates in…
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Quick Read: Can Accutane damage your testicles?
Introduction It’s widely recognised that hormones play an important role in the develop of acne. It’s no coincidence that acne is most prevalent during the teenagehood, where the body rapidly develops under the sudden flood of hormones released from the sex organs (testes or ovaries) as well as the pituitary gland. These hormones play a vital role in guiding the body to develop key secondary sexual characteristics, such as broad…
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