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The Cause of Post Accutane Syndrome
What is the Impact of Accutane on Growth Hormone?
Introduction Somatotropin, more commonly known as Growth Hormone (GH), plays a vital role in signalling cell growth and tissue regeneration throughout the body. This hormone is particularly critical during childhood and adolescence, driving physical development and growth. When GH is secreted excessively, it can lead to conditions like acromegaly, characterised by significant increases in stature and robust skeletal development. One of the most famous individuals associated with this condition is…
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Accutane & Homocysteine: The Impact on the Estrogen Receptor
When reviewing the diverse range of the adverse responses experienced by patients treated with Accutane, one in particular stands out for it’s broad detrimental effects on general health. Accutane can trigger an increase in a particular amino acid called homocysteine. [1] Homocysteine is a byproduct of an essential process known as the methionine cycle. Simply put, methionine is a building block for producing proteins, functioning as an antioxidant, and maintaining…
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What Does Accutane Actually Do?
Introduction Retinoids are the class of chemicals related to vitamin A. The breadth of retinoids’ effects in the body is perhaps greater than that of any other vitamin, including vision, cell proliferation/differentiation, bone tissue, and the immune system. “Retinoid” is a general term that encompasses a range of molecules, including retinol, retinoic acid, and retinyl esters, as well as synthetic retinoids. Vitamin A stands out as one of the most…
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The Fascinating Link Between Accutane and Melatonin
Introduction Despite its now long history of use in treating severe acne, the mechanism underlying Accutane’s efficacy still hasn’t been agreed by practitioners. There are only two known pathways that influence sebum production, PPAR (Peroxisome proliferator-activated receptors) and Androgens. The primary metabolite of Accutane, All-Trans-Retinoic Acid, isn’t usually thought of as having a direct influence on either of these pathways. Nonetheless, there’s increasing evidence to show that Accutane does indeed…
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Does Accutane Get Stored in Your Body?
Introduction Vitamin A plays a key role in a variety of biological processes, from regulating cell growth and differentiation, to the maintenance of eye and skin health. It is classified as a dietary vitamin, as the body cannot synthesise it by itself. The precursor to vitamin A, beta-carotene, can be obtained from plant sources which possess orange and red colours, such as carrots. Additionally, retinyl esters can be obtained from…
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What causes Post Accutane Syndrome?
Introduction Isotretinoin, more commonly known by its brand name Accutane, is a retinoid commonly used to treat severe cystic acne. However, just as it is renowned for permanently treating even the most severe cases of acne, so too does it have the reputation for having a number of nasty side effects. Just as the roles of Vitamin A are broad and diverse, so too as the possible side effects of…
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