Read through my latest articles on Post-Accutane Syndrome.
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Changes to the Brain
Accutane Genetic Risk Factors
Genetic Risk Factors for Post Accutane Syndrome Whilst there’s an increasing awareness of some of the risks posed by isotretinoin treatment, from changes to vision, hair loss and even neurological changes – many dermatologists will still readily write prescriptions. Many who’ve subsequently experienced side effects often claim they weren’t adequately warned of the possible consequences, especially where more enduring symptoms are concerned. Claims of lasting changes to cognitive function appear…
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What Does Accutane Actually Do?
Introduction Retinoids are the class of chemicals related to vitamin A. The breadth of retinoids’ effects in the body is perhaps greater than that of any other vitamin, including vision, cell proliferation/differentiation, bone tissue, and the immune system. “Retinoid” is a general term that encompasses a range of molecules, including retinol, retinoic acid, and retinyl esters, as well as synthetic retinoids. Vitamin A stands out as one of the most…
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SecondLife: Retinoid Recovery Guide
Who’s this book for? As societal trends increasingly emphasize physical appearance, retinoids like Isotretinoin (brand name Accutane) have become a popular solution for acne and fine wrinkles. However, as the use of these medications becomes more widespread, so does awareness of their potential side effects. For most people without a medical background, their understanding of retinoids and Vitamin A is often limited to knowing they are found in red and…
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Accutane & The Prefrontal Cortex
Introduction: In previous articles I’ve explored the diverse and concerning effects of Accutane on the brain. This evidence spans from in vitro experiments showing Isotretinoin directly triggering the death of neurons, to changes to the expression of genes involved in serotonin signalling. [29][30] However, of all the evidence of Accutane’s neurological effects, the most damning of all comes from a 2005 study by Bremner et al. where it was determined…
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Quick Read: Why you shouldn’t drink on Accutane
Introduction Alcohol has always served as a powerful social lubricant, giving a temporary escape from feelings of self consciousness and introversion. This can make it a particularly attractive crutch for those already feeling shy and inhibited by severe cystic acne. Whilst Accutane offers a permanent solution for severe acne, it can still feel tempting to reach out for alcohol during treatment – despite the strong words of warning from doctors.…
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Accutane & Dopamine: Restoring The Reward System
Introduction A meta-analysis involving 25 randomized controlled trials found that neurological complaints were among the most frequent side effects of Accutane treatment. In particular, 24% of subjects experienced severe fatigue, and 10% reported substantial changes in mood and personality. [1] In addition to numerous case studies, there is a strong neuroanatomical basis for the involvement of retinoids in cognition and mood. Specifically, the enzymes responsible for synthesizing retinoic acid are…
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The Fascinating Link Between Accutane and Melatonin
Introduction Despite its now long history of use in treating severe acne, the mechanism underlying Accutane’s efficacy still hasn’t been agreed by practitioners. There are only two known pathways that influence sebum production, PPAR (Peroxisome proliferator-activated receptors) and Androgens. The primary metabolite of Accutane, All-Trans-Retinoic Acid, isn’t usually thought of as having a direct influence on either of these pathways. Nonetheless, there’s increasing evidence to show that Accutane does indeed…
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PPAR: The Link Between The Gut, Allopregnanolone And The Brain
Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors to regulate metabolic health. There are three types of PPARs: alpha, gamma and delta. When bound to by fatty acids (such as prostaglandins) influence processes such as fat burning, lipid storage and glucose metabolism. [1] Among the long list of side effects of Accutane, at the top of the list of immediate concern is…
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Lithium: The ‘Anti-Accutane’ Supplement?
Introduction Contrary to popular opinion lithium isn’t just a medication for the Manic and Psychotic, in fact, it’s in your water (at very very low doses). The World Health Organisation even recognises it as an essential mineral. Despite its long history as an antipsychotic, recent research has uncovered new and intriguing effects of this trace metal on brain health and epigenetics. Remarkably, lithium supplementation may also provide benefits for those experiencing…
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Accutane and Serotonin: Revealing Its Effects on Mood, Libido, and Cognitive Function
Introduction Accutane, also known by its generic name Isotretinoin, is a widely used retinoid, primarily prescribed for the treatment of severe acne. Over the years its effectiveness in treating stubborn, severe acne has been well-documented, however its profound neurological effects are now equally well-documented. The first recorded case attesting these psychological changes rather bizarrely comes from an artic explorer, Elisha Kane, are ingesting the retinoid-rich liver of a polar bear.…
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How Accutane Changes Your Brain
Introduction Accutane, also known by its generic name isotretinoin, is a widely used medication primarily prescribed for the treatment of severe acne. Over the years, its effectiveness in treating severe acne has been well-documented, earning it a reputation as a potent solution when other treatments fail. However, despite its efficacy, it has also been associated with a range of potential side effects—particularly those affecting the brain. The extent of its…
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